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Anti age lipoic complex Cream

77,00 € each Weight: 50 g


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Anti age lipoic complex Cream has as main ingredient lipoic acid which makes its formulation very interesting.
It allows ingredients of other creams used with it to penetrate into the skin , increasing the efficacity.
It is recommended to use it in combination with Peeling de Luxe as 1 st step Anti age lipoic complex Cream, 2 nd step TCA 8 or 10%, 3rd step peeling de luxe.
Its indications are the followings :

  • to treat the stretch marks ( Anti age lipoic complex Cream as 1 st step, Peeling de Luxe as 2 nd step - before going to bed) - each day until you get results but you begin to see an approvemnt from the 5 th day of application.
  • to treat the wrinkles ( same protocol as for stretch marks)
  • for men, it is recommended to use it after hair removal.

Possible beneficial effects 

Lipoic acid has been the subject of numerous research studies and clinical trials:

 

  • Accelerate chronic wound healing
  • Reduce iron overload
  • Prevent or slow the progression of Alzheimer’s Disease
  • Treat chronic diseases associated with oxidative stress
  • Reduce inflammation
  • Treat peripheral artery disease.

 

References[edit]

  1. ^ Alleva, R, Nasole, E, Di Donato, F, Borghi, B, Neuzil, J, Tomasetti, M (July 2005). "alpha-Lipoic acid supplementation inhibits oxidative damage, accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy". Biochemical and Biophysical Research Communications333 (2): 404–10. doi:10.1016/j.bbrc.2005.05.119PMID 15950945.
  2. ^ Kundiev, IuI, Lubianova, IP, Mikhaĭlik, OM, Dudchenko, NO, Lampeka, EG (2001). "Berlition R 300 oral -- alpha-lipoic acid preparation for the correction of body changes associated with high serum iron content". Meditsina truda i promyshlennaia ekologiia (1): 14–8. PMID 11221104.
  3. ^ Holmquist, L, Stuchbury, G, Berbaum, K, Muscat, S, Young, S, Hager, K, Engel, J, Münch, G (January 2007). "Lipoic acid as a novel treatment for Alzheimer's disease and related dementias". Pharmacology & therapeutics 113 (1): 154–64. doi:10.1016/j.pharmthera.2006.07.001.PMID 16989905.
  4. ^ Hager, K, Kenklies, M, McAfoose, J, Engel, J, Münch, G (2007). "Alpha-lipoic acid as a new treatment option for Alzheimer's disease—a 48 months follow-up analysis". Journal of neural transmission. Supplementum (72): 189–93. PMID 17982894.
  5. ^ MacZurek, A, Hager, K, Kenklies, M, Sharman, M, Martins, R, Engel, J, Carlson, DA, Münch, G (2008). "Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease". Advanced drug delivery reviews 60 (13–14): 1463–70. doi:10.1016/j.addr.2008.04.015.PMID 18655815.
  6. ^ Smith, AR, Shenvi, SV, Widlansky, M, Suh, JH, Hagen, TM (May 2004). "Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress". Current medicinal chemistry 11 (9): 1135–46. PMID 15134511.
  7. ^ Zhang WJ, Wei H, Hagen T, Frei B (2007). "α-Lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway"Proc Natl Acad Sci U S A. 104 (10): 4077–82. doi:10.1073/pnas.0700305104PMC 1805485.PMID 17360480.
  8. ^ Vincent, HK, Bourguignon, CM, Vincent, KR, Taylor, AG (June 2007). "Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study". Journal of alternative and complementary medicine 13 (5): 577–84. doi:10.1089/acm.2007.6177PMID 17604563.
  9. a b Kleeman A, Borbe HO, Ulrich H. Thioctic Acid-Lipoic Acid; in Thioctic Acid. New Biochemistry, Pharmacology and Findings from Clinical Practice with Thioctic Acid. 11-26. Borbe; Ulrich (Hrsg.) Verfasser: Reschke, Barbara ; Borbe, Harald [Hrsg.]Verleger: [Frankfurt (Main)] : pmi (1991)
  10. ^ Hiraizumi G (1959). "Alpha Lipoic Acid Metabolism in Various Diseases. II. The Urinary Excretion and Serum level of Alpha Lipoic Acid in Patients with Various Diseases". Bitamin 18 (1): 184–8.
  11. ^ Wada M, Hiraizumi G, Shigeta Y (1960). "The Urinary Excretion and Serum Level of a-lipoic acid in Patients with Several Diseases".Maikurobaioassei (Microbioassay) 1: 53–5.
  12. ^ http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">http://www.direct-ms.org/pdf/NutritionNonAuto/Ames%20Delaying%20Aging%20with%20ALCAR.pdf
  13. ^ Gal, EM, Razevska, DE (August 1960). "Studies on the in vivo metabolism of lipoic acid. 1. The fate of DL-lipoic acid-S35 in normal and thiamine-deficient rats". Archives of biochemistry and biophysics 89 (2): 253–61. doi:10.1016/0003-9861(60)90051-5PMID 13825981.
  14. a b Gal, EM (July 1965). "Reversal of selective toxicity of (-)-alpha-lipoic acid by thiamine in thiamine-deficient rats". Nature 207 (996): 535.doi:10.1038/207535a0PMID 5328673.
  15. ^ Lecoq, R, Chauchard, P, Mazoue, H (October 1958). "Comparative chronaxymetric research on the effects of several vitaminic substances (stigmasterol, carnitine, thioctic acid)". Comptes rendus hebdomadaires des séances de l'Académie des sciences 247 (17): 1411–3.PMID 13609011.
  16. ^ McCarty, MF (April 1981). "Toward a "bio-energy supplement" -- a prototype for functional orthomolecular supplementation". Medical hypotheses 7(4): 515–38. doi:10.1016/0306-9877(81)90038-4PMID 6793816.
  17. ^ Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN (Sep 1998). "Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementation". FASEB J. 12 (12): 1183–9. PMID 9737721.
  18. ^ Hagen, TM, Ingersoll, RT, Lykkesfeldt, J, Liu, J, Wehr, CM, Vinarsky, V, Bartholomew, JC, Ames, AB (February 1999). "(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate". The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 13 (2): 411–8. PMID 9973329.
  19. ^ Hagen, TM, Vinarsky, V, Wehr, CM, Ames, BN (2000). "(R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo". Antioxidants & redox signaling 2 (3): 473–83. doi:10.1089/15230860050192251.PMID 11229361.
  20. ^ Hagen, TM, Liu, J, Lykkesfeldt, J, Wehr, CM, Ingersoll, RT, Vinarsky, V, Bartholomew, JC, Ames, BN (February 2002). "Feeding acetyl-l-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress"Proceedings of the National Academy of Sciences of the United States of America 99 (4): 1870–5. doi:10.1073/pnas.261708898PMC 122286PMID 11854487.
  21. ^ Liu, J; Head, E; Gharib, AM; Yuan, W; Ingersoll, RT; Hagen, TM; Cotman, CW; Ames, BN (2002). "Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-l-carnitine and/or R-α-lipoic acid"Proceedings of the National Academy of Sciences of the United States of America 99 (4): 2356–61. doi:10.1073/pnas.261709299PMC 122369PMID 11854529.Erratum in: Proc Natl Acad Sci U S A 2002 May 14;99(10):7184-5
  22. a b Packer & Patel 2008, Petersen-Shay K, Shenvi S, Hagen TM. Ch. 14 "Lipoic acid as an inducer of phase II detoxification enzymes through activation of Nr-f2 dependent gene expression." pp. 349–371
  23. ^ Lii CK, Liu KL, Cheng YP, Lin AH, Chen HW, Tsai CW (May 2010). "Sulforaphane and alpha-lipoic acid upregulate the expression of the pi class of glutathione S-transferase through c-jun and Nrf2 activation"J. Nutr. 140 (5): 885–92. doi:10.3945/jn.110.121418PMID 20237067.
  24. a b c Carlson, DA, Smith, AR, Fischer, SJ, Young, KL, Packer, L (December 2007). "The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects". Alternative medicine review : a journal of clinical therapeutic 12 (4): 343–51. PMID 18069903.
  25. ^ Hill AS et al., J Anim Physiol Anim Nutr (Berl.), 2004 Apr;88(3-4):150-6
  26. ^ Arnér, ES, Nordberg, J, Holmgren, A (August 1996). "Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase".Biochemical and Biophysical Research Communications 225 (1): 268–74. doi:10.1006/bbrc.1996.1165PMID 8769129.
  27. ^ Biaglow, JE, Ayene, IS, Koch, CJ, Donahue, J, Stamato, TD, Mieyal, JJ, Tuttle, SW (April 2003). "Radiation response of cells during altered protein thiol redox". Radiation research 159 (4): 484–94. doi:10.1667/0033-7587(2003)159[0484:RROCDA]2.0.CO;2PMID 12643793.
  28. ^ Haramaki, N, Han, D, Handelman, GJ, Tritschler, HJ, Packer, L (1997). "Cytosolic and mitochondrial systems for NADH- and NADPH-dependent reduction of alpha-lipoic acid". Free radical biology & medicine 22 (3): 535–42. doi:10.1016/S0891-5849(96)00400-5PMID 8981046.
  29. ^ Constantinescu, A, Pick, U, Handelman, GJ, Haramaki, N, Han, D, Podda, M, Tritschler, HJ, Packer, L (July 1995). "Reduction and transport of lipoic acid by human erythrocytes". Biochemical pharmacology 50 (2): 253–61. doi:10.1016/0006-2952(95)00084-DPMID 7632170.
  30. ^ May, JM, Qu, ZC, Nelson, DJ (June 2006). "Cellular disulfide-reducing capacity: an integrated measure of cell redox capacity". Biochemical and Biophysical Research Communications 344 (4): 1352–9. doi:10.1016/j.bbrc.2006.04.065PMID 16650819.
  31. ^ Jones, W, Li, X, Qu, ZC, Perriott, L, Whitesell, RR, May, JM (July 2002). "Uptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cells". Free radical biology & medicine 33 (1): 83–93. doi:10.1016/S0891-5849(02)00862-6PMID 12086686.
  32. ^ Schempp H, Ulrich H, Elstner EF (1994). "Stereospecific reduction of R(+)-thioctic acid by porcine heart lipoamide dehydrogenase/diaphorase". Z. Naturforsch., C, J. Biosci. 49 (9-10): 691–2. PMID 7945680.
  33. ^ Biewenga G Ph, Haenen GRMM, Bast A (1997). "Ch. 1 "An overview of Lipoate Chemistry"". In Fuchs J, Packer L, Zimmer G. Lipoic Acid In Health & Disease. Marcel Dekker. pp. 1–32.
  34. ^ Sen CK (1997). "Nutritional Biochemistry of Cellular Glutathione". Nutritional Biochemistry 8 (12): 660–672. doi:10.1016/S0955-2863(97)00113-7.
  35. ^ Marí, M, Morales, A, Colell, A, García-Ruiz, C, Fernández-Checa, JC (November 2009). "Mitochondrial Glutathione, a Key Survival Antioxidant".Antioxidants & redox signaling 11 (11): 2685–700. doi:10.1089/ARS.2009.2695PMC 2821140PMID 19558212.
  36. a b Packer, L, Witt, EH, Tritschler, HJ (August 1995). "alpha-Lipoic acid as a biological antioxidant". Free radical biology & medicine 19 (2): 227–50.doi:10.1016/0891-5849(95)00017-RPMID 7649494.
  37. ^ Harrison, EH, McCormick, DB (February 1974). "The metabolism of dl-(1,6-14C)lipoic acid in the rat". Archives of biochemistry and biophysics 160(2): 514–22. doi:10.1016/0003-9861(74)90428-7PMID 4598618.
  38. ^ Schupke, H, Hempel, R, Peter, G, Hermann, R, Wessel, K, Engel, J, Kronbach, T (June 2001). "New metabolic pathways of alpha-lipoic acid". Drug metabolism and disposition: the biological fate of chemicals 29 (6): 855–62. PMID 11353754.
  39. ^ Rosenberg, H (1959). "Effect of ?-lipoic acid on vitamin C and vitamin E deficiencies". Archives of Biochemistry and Biophysics 80: 86–93.doi:10.1016/0003-9861(59)90345-5.
  40. ^ Haenen, GRMM, Bast, A (1991). "Scavenging of hypochlorous acid by lipoic acid". Biochem Pharmacol 42 (11): 2244–6. doi:10.1016/0006-2952(91)90363-APMID 1659823.
  41. a b Packer & Patel 2008, Carlson DA, Young KL, Fischer SJ, Ulrich H. Ch. 10 "An Evaluation of the Stability and Pharmacokinetics of R-lipoic Acid and R-Dihydrolipoic Acid Dosage Forms in Plasma from Healthy Human Subjects." pp. 235–270
  42. ^ Gregus, Z.; Stein, A.F, Varga, F., Klaassen, C.D. (1992). "Effect of lipoic acid on biliary excretion of glutathione and metals". Toxicology and Applied Pharmacology 114 (1): 88–96. doi:10.1016/0041-008X(92)90100-7PMID 1585376.
  43. ^ Rooney, James, (2007). "The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury". Toxicology 234 (3): 145–156. doi:10.1016/j.tox.2007.02.016PMID 17408840.
  44. ^ Fontanella, L (1955). "Preparation of optical antipodes of alpha-lipoic acid". Il Farmaco; edizione scientifica 10 (12): 1043–5. PMID 13294188.
  45. ^ Walton E, Wagner AF, Bachelor FW, Peterson LH, Holly FW, Folkers K (1955). "Synthesis of (+)-Lipoic Acid and its Optical Antipode". J. Am. Chem. Soc. 77 (19): 5144–9. doi:10.1021/ja01624a057.
  46. ^ Acker DS, Wayne WJ. (1957). "Optically Active and Radioactive α-Lipoic Acids". J. Am. Chem. Soc. 79: 6483. doi:10.1021/ja01581a033.
  47. ^ Deguchi, Y, Miura, K (June 1964). "Studies on the Synthesis of Thioctic acid and its related compounds. XIV. Synthesis of (+)-Thioctamide".Yakugaku Zasshi 84: 562–3. PMID 14207116.
  48. ^ Lang G. In Vitro Metabolism of a-Lipoic Acid Especially Taking Enantioselective Bio-transformation into Account. Ph.D. Thesis, University of Münster, Münster,Germany (1992)
  49. ^ Blaschke et al. Preparation and use of salts of the pure enantiomers of alpha-lipoic acid. US 5281722 (Jan 25, 1994)
  50. ^ Packer, L, Kraemer, K, Rimbach, G (October 2001). "Molecular aspects of lipoic acid in the prevention of diabetes complications". Nutrition (Burbank, Los Angeles County, Calif.)  Brand URL : http://www.cosmeticpeeling.com/buy-endopeel-and-peels/anti-age/product/14-anti-age-lipoic-complex-cream

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